Lexington is the county seat of Davidson County, North Carolina, United States. As of the 2020 census, the town had a population of 19,632. I…Lexington is the county seat of Davidson County, North Carolina, United States. As of the 2020 census, the town had a population of 19,632. It is located in central North Carolina, 20 miles south of Winston-Salem. Major highways include I-85, I-85B, U.S. Route 29, U.S. Route 70, U.S. Route 52 / I-285 and U.S. Route 64. Lexington is part of the Piedmont Triad region of the state.