Sep 25, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) and head coach Jonathan Gannon talk before the game against the Seattle Seahawks at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images / Joe Camporeale-Imagn Images

The Indianapolis Colts rally in the fourth quarter to defeat the Arizona Cardinals. Here are the winners and losers from the NFL Week 6 matchup.

"Anything can happen in a 1-game sample. But Jacoby Brissett started 5 games and dropped back 188 times for Patriots last season. Brissett completed just 59% of his passes, didn’t throw for more than 168 yards in a game, threw 2 TDs. Only Will Levis was worse in EPA per dropback."

Still tinkering with your lineup? We've got your last-minute updates for DFS and season-long fantasy football starts and sits. Featuring Bam Knight.

The Indianapolis Colts may see a familiar face at quarterback for the Arizona Cardinals on Sunday. According to Ian Rapoport, the Cardinals are "preparing" for Jacoby Brissett to start in the Week 6 game.