Sequence variation in human genes is largely confined to single-nucleotide polymorphisms (SNPs) and is valuable in tests of association with common diseases and pharmacogenetic traits. We performed a ...

The enzyme human steroid 5-α reductase type II (SRD5A2) and androgen receptor (AR) are critical mediators of androgen action, suggesting a potential role in hormonally related cancers. The SRD5A2 gene ...

A research team led by Profs. XU Tao and HE Shunmin from the Institute of Biophysics of the Chinese Academy of Sciences has recently constructed a global polymorphism genetic map of variable number ...

1982 The Human Polymorphism Study Center, the first academic institution to propose the systematic study of polymorphisms, is founded in Paris. Its primary objective: to make an inventory of all ...

In a recent study published in Immunity, researchers isolated SARS-CoV-2 spike (S) protein-targeted mAbs (monoclonal antibodies) from convalescent healthcare workers (HCWs), emphasizing the IGHV1-69 ...

Through sophisticated statistical analyses and advanced computer simulations, researchers are learning more about the genomic patterns of human population structure around the world. Revealing such ...

Phenotypes of human red cell esterase D (EsD) were determined in 351 unrelated adults from Serbia (Yugoslavia). The calculated allele frequencies were 0.911 for EsD¹ and 0.089 for EsD². The phenotype ...