Get the opening NFL Week 10 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Nov. 6, 2025.

Las Vegas won 19-14 on Dec. 22, 2024, in the Jaguars’ first visit to Allegiant Stadium.

The Vegas Golden Knights (6-1-3) and Jack Eichel (eight goals and 11 assists) host the Colorado Avalanche (6-1-4) and Nathan MacKinnon (nine goals and eight assists) at T-Mobile Arena on Friday, Oct. 31 at 4 p.m. ET, airing on ESPN+. In its last game on Oct. 28, Colorado earned an 8-4 home victory over the New Jersey Devils.

The NASCAR Cup Series continues the season at Las Vegas with Sunday's South Point 400. Here are the betting odds for Sunday's race.

The first week after the time change. If I miss all of my picks this week, that's why. Turning the clock back and getting an extra hour of sleep sounds great in theory, but in reality, there is NO extra sleep for anyone in my house because I live with two kids under the age of five who don't believe in time changes.

A look at who is predicted to lead the NFL in total TDs in Week 10, plus accompanying player prop betting odds.

Kyle Larson is the betting favorite to win at Las Vegas, despite not having won a race since May. One of the eliminated playoff drivers — Shane van Gisbergen — won last week at Charlotte, but that was no surprise since the race was on Charlotte’s Roval.