No double-digit favorites have lost yet in the 2025 NFL season, but Week 3 did bring perhaps the biggest upset of the year thus far as the Packers fell to the Browns as 7.5-point favorites. That was one of the first big hits for NFL survivor players,

According to Circa’s “ availability matrix ,” two of the most already-used teams are the Cardinals (third most at 53.3%) and the Bills (most at 57.4%). Naturally, the choice for Week 5 is between those two teams.