Figure 1: Cellular localization of CRF peptide, CRFR1 and CRFR2 in the nucleus accumbens. Figure 2: CRF increases dopamine release in the nucleus accumbens through coactivation of CRFR1 and CRFR2.

Drug abuse is thought to induce long-term cellular and behavioral adaptations as a result of alterations in gene expression. Understanding the molecular consequences of addiction may contribute to the ...

In a study using genetically modified mice, researchers found that the nucleus accumbens recruited by cocaine use are largely distinct from nucleus accumbens recruited by sucrose, or table sugar.

A new study has revealed that cannabidiol, a non-intoxicating compound found in the cannabis plant, may help prevent opioid ...

Reward-seeking and threat avoidance are critical for survival. Pursuing enjoyable things triggers the release of dopamine in the brain, making people feel pleasure. On the contrary, people ...

A rare brain-recording study found tirzepatide briefly muted activity linked to 'food noise'; months later the signals and ...

Understanding the dynamic neural mechanisms of sleep-wake cycles is a major challenge in sleep science and neuroengineering.