In this perspective, we will first describe the historical underpinnings of longstanding concepts of how antibodies protect against microbes and then introduce newly identified mechanisms of antibody ...

The complement system consists of a complex set of approximately 20 interacting proteolytic enzymes and regulatory proteins found in the plasma and body fluids. [6] Complement proteins are effector ...

Illustrative diagram of the two main approaches of the antibacterial therapeutic antibodies. In the direct approach, three possible modes of action can occur; inactivate pathogens and toxins by ...

The complement system has an important role in neuroinflammation, both in the pathogenesis of Alzheimer’s disease and in the most severe infections affecting the central nervous system such as ...

EMPAVELI's unique mechanism of targeting C3 broadens its applicability beyond PNH, including other complement-driven diseases like geographic atrophy and immune complex-mediated diseases. With a high ...