Enzymes that cut DNA at specific sites are called endonucleases; these enzymes play many roles in genomic replication, fidelity, and defense. The initial discovery of restriction endonucleases in the ...

In human cells, there are about 20,000 genes on a two-meter DNA strand—finely coiled up in a nucleus about 10 micrometers in ...

There are many health problems that can be traced back to errors in the genetic code. There are also many potential benefits to genetic engineering outside of healthcare. Nature has already found ways ...

Epigenetics is the study of how our cells alter their function by modifying gene expression in our genetic code or deoxyribonucleic acid (DNA). In our cells, DNA is constantly being used to generate ...

Genetic medicines R&D is making strides with more complex DNA molecules. While these long sequences of synthetic DNA are key for developing gene and cell therapies as well as antibodies and other ...

In humans and other eukaryotes, two principal epigenetic marks are known. A team has discovered a third, novel epigenetic mark -- one formerly known only in bacteria -- in bdelloid rotifers, small ...

Loss of Polβ leads to increased mutations in developing neurons, potentially contributing to neurodevelopmental disorders.A ...

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research. The human nucleus is ...

The nucleus has historically been considered to be metabolically inert, importing all its needs through supply chains in the cytoplasm. Now, a new study by researchers at the Centre for Genomic ...

A research group led by the University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a ...