Riding a three-game win streak, the Rams will look to keep that momentum going approaching a Week 10 showdown against divisional rival San Francisco at Levi's Stadium. Kickoff against the 49ers in Santa Clara is scheduled for 1:25 p.m. pacific time on FOX.

After one week back at home in Los Angeles, the Rams will be on the road again in Week 10 for a pivotal matchup with the San Francisco 49ers. It’s a rematch of their Week 5 game that went into overtime, only for the 49ers to win on a field goal and subsequent fourth-down stop in the final minutes.

Get the full 49ers Week 10 practice and media schedule ahead of their matchup vs. the Rams, including press conferences and practice times.

Since the injury avalanche hit the 49ers have managed to keep their heads above water and not suffer any bad losses. After losing in Week 8 to the Houston Texans on the road, the spotlight gets a little brighter for a group that has been pushed into bigger roles with a handful of injuries for San Francisco on both sides of the ball.

Here is where the San Francisco 49ers sit in the 2025 NFL Week 10 power rankings after their win over the New York Giants.

The Rams made it look easy against the Saints on Sunday, cruising to big 24-point win in their return from the bye.

The Los Angeles Rams were off in Week 8 for their bye week, but that set them up well as they played host to the New Orleans Saints in Week 9. While the Rams remain in a heated competition to stay atop the NFC West,

The San Francisco 49ers beat the New York Giants 34-24 on Sunday. Here are some of the best photos from the Week 9 win.