This Perspective takes the reader through the important steps in bacterial genome assembly and activation and concludes with an outlook on how customized genomes may be achieved. The DNA ...

This Review discusses the considerations for designing cancer genome-sequencing studies to fulfil different study aims, such as detecting recurrent mutations or assessing clonal evolution. For ...

However, the ability to write a genome from scratch would unlock greater creativity in designing a desired genome — your dream home — and producing new kinds of organisms that do things that nature ...

Scientists discover next-generation system for programmable genome design. ... The study published today in Nature reports their ... The Hsu lab found that when IS110 excises itself from a genome, ...

In the past decade or so, biomedical technology has been revolutionized by a gene editing technique known as CRISPR, which uses a guide RNA molecule to direct a DNA-cutting enzyme to a specific ...

These modular, bi-specific bridge RNAs can be reprogrammed to enable sequence-specific fundamental DNA rearrangements, potentially accelerating the advancement of genome design (Fig 1). 2 ...

“The ability to programmably rearrange any two DNA molecules opens the door to breakthroughs in genome design.” Read the papers in Nature here and here. A short video of the discovery, ...

The paper, by C.A. Hutchison III at J. Craig Venter Institute in La Jolla, Calif., and colleagues was titled, "Design and synthesis of a minimal bacterial genome." C. Bickel / Science (2016) ...

Nature vs Nurture Revisited by Kevin Davies The most shocking surprise that emerged from the full sequence of the human genome earlier this year is that we are the proud owners of a paltry 30,000 ...

The findings, which reveal how the physical nature of the genome changes as cells transform to serve specific functions, point to new ways to potentially better understand disease and to create ...

“The Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature ...

Scientists Unveil a More Diverse Human Genome The “pangenome,” which collated genetic sequences from 47 people of diverse ethnic backgrounds, could greatly expand the reach of personalized ...