Jacoby Brissett, filling in for an injured Kyler Murray, finished 27-for-44 for 320 yards and two touchdowns with one interception.

The Indianapolis Colts take the AFC South lead by extending the Arizona Cardinals' losing streak: Stats, scores.

Puka Nacua, Emeka Egbuka and Marvin Harrison Jr. were among the NFL players injured in Week 6 of the 2025 NFL season. They ...

The Arizona Cardinals hope to snap a three-game losing streak in Week 6. They face the 4-1 Indianapolis Colts on the road on Sunday.

For four excruciating weeks, the Cardinals had a chance, and they dropped each one. Three losses came on late field goals. In ...

Tight end Travis Vokolek was carted off in the first quarter with a neck injury and was transported to a local hospital ...

Travis Vokolek was injured on what appeared to be an unremarkable play on a kickoff vs Colts at Lucas Oil Stadium ...

Tampa Bay quarterback Baker Mayfield piloted the Buccaneers to a 30-19 NFL victory over the San Francisco 49ers on Sunday in ...

The Arizona Cardinals are now 2-4 on the season following their 31-27 loss to the Indianapolis Colts in Week 6. Without Kyler Murray due to a foot injury, it was Jacoby Brissett who got the nod in his ...

Colts: Indy ruled out two players — starting CB Kenny Moore II (Achilles tendon) and backup RB Tyler Goodson (groin) — on Friday, and then lost starting CB Charvarius Ward (concussion) and backup QB ...

Despite Jacoby Brissett's strong start against the Colts, Cardinals head coach Jonathan Gannon said Kyler Murray remains the starter when healthy.

Colts locker room was rocked by pregame injuries to QB Anthony Richardson and CB Charvarius Ward. Players prayed for their teammates, and themselves.