This article was originally published on www.si.com/college/iowa-state as Iowa State Cyclones Defender Gets Selected by Chargers in 2026 Mock Draft.

The Colorado Buffaloes defeated the No. 21 Iowa State Cyclones 24-21 at Folsom Field. Quarterback Kaidon Salter threw for 255 yards and two touchdowns in the victory. Colorado's defense held Iowa State to 2 for 12 on third downs and secured a key interception.

The Colorado Buffaloes earned their first Big 12 conference win of the season, pulling off the upset against the No. 22 Iowa State Cyclones, 24-17. Colorado coa

Colorado and coach Deion Sanders rebounded from a difficult stretch to defeat No. 21 Iowa State with key plays on offense and defense.

Kickoff from Folsom Field in Boulder, Colo. is set for 3:30 p.m. ET. The Cyclones are 3-point favorites in the latest Iowa State vs. Colorado odds, while the over/under for total points scored is 51.5. Before making any Colorado vs. Iowa State picks, make sure you check out what SportsLine college football expert Jimmie Kaylor has to say .

The Iowa State Cyclones knew that they had some huge shoes to fill on the offensive side of the ball this offseason. Their top two wide receivers from 2024, Jayden Higgins and Jaylin Noel, were both off to the professional ranks.

Iowa State football running back Ryver Peppers was helped off the field before heading to the locker room in his team's Week 7 game against Colorado on Saturday, Oct. 11. According to the broadcast, the injury occurred on the first career snap for the true freshman from Independence, Missouri.