"Anything can happen in a 1-game sample. But Jacoby Brissett started 5 games and dropped back 188 times for Patriots last season. Brissett completed just 59% of his passes, didn’t throw for more than 168 yards in a game, threw 2 TDs. Only Will Levis was worse in EPA per dropback."

The Indianapolis Colts rally in the fourth quarter to defeat the Arizona Cardinals. Here are the winners and losers from the NFL Week 6 matchup.

Sep 25, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) and head coach Jonathan Gannon talk before the game against the Seattle Seahawks at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images / Joe Camporeale-Imagn Images

Brissett completed 27 of 44 passes for 320 yards with two touchdowns and one interception while adding three rushes for 19 yards in the Cardinals ' 31-27 loss to the Colts on Sunday.

Jacoby Brissett is confident he can lead the offense in place of Kyler Murray if asked to step up for the Cardinals this weekend against the Colts.