Both systemic sclerosis and systemic lupus erythematosus have down-regulated RGS5, but they also have distinctive genetic expression profiles.

A 28-year-old woman was admitted to the hospital because of severe hypoxemia and right heart failure that had been caused by rapidly progressive pulmonary hypertension. A diagnosis was made.

Patients with SSc vs controls showed a greater prevalence of WMH on brain MRIs, particularly in deep white matter regions.