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Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)
9 European Union (EU) Innovative Medicines Initiative (IMI) Program Understanding Severe Asthma, Consortium Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) ...
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Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study
12 Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada Correspondence to Dr Wan C Tan, UBC James Hogg Research Centre, Providence Heart+Lung Institute, University of ...
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Gene expression networks in COPD: microRNA and mRNA regulation
1 Department of Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA Background The mechanisms underlying chronic obstructive ...
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S103 Clinical effectiveness of tezepelumab on upper and lower respiratory symptoms in patients with asthma and co-morbid nasal polyposis
Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...
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High-intensity training following lung cancer surgery: a randomised controlled trial
Correspondence to Elisabeth Edvardsen, Department of Pulmonary Medicine, Oslo University Hospital, Ullevål, P.O. Box 4953 Nydalen, 0424 Oslo, Norway; elisabeth.edvardsen{at}nih.no Background Many ...
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How much asthma is really attributable to atopy?
a Wellington Asthma Research Group, Wellington School of Medicine, P.O. Box 7343, Wellington, New Zealand, b Unit of Environmental Epidemiology, National Public Health Institute, P. O. Box 95, Kuopio, ...
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Summary of effects of parental smoking on the respiratory health of children and implications for research
BACKGROUND Two recent reviews have assessed the effect of parental smoking on respiratory disease in children. METHODS The results of the systematic quantitative review published as a series inThorax ...
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Effect of vitamin A on adult lung function: a triangulation of evidence approach
Background Vitamin A, an essential micronutrient obtained through the diet, plays a crucial role in lung development and contributes to lung regeneration. We aimed to investigate its effect on adult ...
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Telerehabilitation for chronic respiratory disease: a randomised controlled equivalence trial
Rationale Pulmonary rehabilitation is an effective treatment for people with chronic respiratory disease but is delivered to <5% of eligible individuals. This study investigated whether home-based ...
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Observational study of the effect of obesity on lung volumes
Background Severe obesity causes respiratory morbidity and mortality. The impact of obesity on the mechanics of breathing is not fully understood. Conclusions Obese subjects have markedly increased ...
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Sleep · 1: Obstructive sleep apnoea/hypopnoea syndrome: definitions, epidemiology, and natural history
Oxford Centre for Respiratory Medicine, University of Oxford and Churchill Hospital, Oxford OX3 7LJ, UK Correspondence to: Professor J R Stradling Oxford Centre for Respiratory Medicine, University of ...
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Inflammation in preschool cystic fibrosis is of mixed phenotype, extends beyond the lung and is differentially modified by CFTR modulators
Background Early-life inflammation has long been recognised as a key pathophysiological process in the evolution of cystic ...