Of the three B cell subsets, FO B cells preferentially undergo T cell-dependent activation while MZ B cells and B1 B cells preferentially undergo T cell-independent activation.

Apr 29, 2025 · Explore the intricate processes of B cell activation, antibody production, and their role in sustaining long-term immunity.

Mar 6, 2025 · B cell activation usually occurs in the spleen or other secondary lymphoid organs like lymph nodes. After maturation in the bone marrow, the cells migrate to lymphoid organs as …

In order for the B cell to be activated, the antigen first needs to bind to and induce the crosslinking of the B cell receptors. When two B cell receptors get crosslinked, their intracellular chains, the …

Sep 4, 2022 · B cell activation is the process that precedes the transformation of B cells to plasma cells and memory B cells. The plasma cells in turn produce antibodies. The antibodies serve a …

Once a B cell is activated, it undergoes clonal proliferation (clonal expansion) and daughter cells differentiate into plasma cells. Plasma cells are antibody factories that secrete large quantities …

Nov 29, 2025 · A B cell becomes activated when its receptor recognizes an antigen and binds to it. In most cases, however, B-cell activation is dependent on a second factor mentioned …

Here we review current understanding of how B cell responses are initiated, the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells, and how …

May 1, 2024 · Our review explores the nuances of B cell signal transduction, elucidating the complex interplay of various molecules and pathways involved in orchestrating B cell …

B cell activation is integral for the pathogen-recognition abilities of the human immune system. When B cells encounter specific antigens and activate, they become plasma cells that produce …