Jun 19, 2025 · Herpes simplex virus type 1 (HSV-1) remodels the host chromatin structure and induces a host-to-virus transcriptional switch during lytic infection. We combine super-resolution imaging...

Although members of this family differ in tissue tropism and many aspects of their interactions with their hosts, the mechanisms by which they replicate their DNA during productive (“lytic”) infection are …

Oct 1, 2021 · In this review, we summarize recent findings on the ultrastructure of tegumented capsids and how incoming, cytosolic capsids utilize microtubules (MTs) for transport from the cell periphery …

Mar 17, 2025 · (A; lower left) In the host cell nucleus, HSV-1 DNA is replicated, and a protein capsid that encloses the viral genome is assembled. These capsids (purple hexagons) bind to pUL34, a …

Aug 9, 2012 · Latent HSV-1 dsDNA genomes localize in the nucleus of the host neuron where they remain as multi-copy chromatinized episomes, which do not integrate into the host-cell genome [2], [3].

The genome of HHV-1 is linear, double stranded DNA composed of 152,000 base pairs. It contains two unique regions (UL and US), each flanked by inverted repeats (TRL/IRL and TRS/IRS). This …

Jun 16, 2025 · Herpes Simplex Virus Type 1 (HSV-1) is a large, double-stranded DNA virus with a remarkable capacity for neural latency, periodic reactivation, and widespread transmission.

Jun 19, 2025 · Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have discovered the cold sore virus reshapes the human genome's architecture, rearranging its shape in three …

First, complementary viral and cell surface receptors bring the viral and host cell membranes into close proximity. Next, the two membranes begin to merge, forming a hemifusion state. Finally, a stable …

Jun 20, 2025 · Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have discovered the cold sore virus reshapes the human genome’s architecture, rearranging its shape in three …