PRDM16 controls the cell fate between muscle and brown fat cells. Loss of PRDM16 from brown fat precursors causes a loss of brown fat characteristics and promotes muscle differentiation.

Nov 14, 2025 · PRDM16 (PR/SET Domain 16) is a Protein Coding gene. Diseases associated with PRDM16 include Left Ventricular Noncompaction 8 and Left Ventricular Noncompaction. …

The PR-domain containing 16 (Prdm16) protein is a powerful inducer of the thermogenic phenotype in fat cells. In both developmental (brown) and induced (beige) thermogenic …

Aug 17, 2022 · PR domain-containing 16 (PRDM16) is a dominant activator of the biogenesis of beige adipocytes by forming a complex with transcriptional and epigenetic factors and is …

May 29, 2025 · In this review, we give a synopsis of PRDM16's expression and function within (developing) cardiovascular tissues and provide insights into how impaired PRDM16 signalling …

Apr 8, 2022 · In this review, we summarize the evidence of PRDM16 involvement in the progression of obesity and diabetes and that PRDM16 may be a promising therapy for obesity …

Apr 3, 2023 · PRDM16 plays an important role in maintaining mitochondrial function, preventing oxidative stress, and inhibiting cardiac hypertrophy (Cibi et al., 2020).

Recent research has underscored the vital role of PRDM16 in the development and functionality of thermogenic adipocytes. Consequently, PRDM16 has been identified as a potential …

PRDM16, also known as PR domain containing 16, is a protein encoded by the PRDM16 gene in humans. It functions as a transcription coregulator that controls the development of brown …

Sep 1, 2024 · We have discussed the diverse biological functions of PRDM16 in adipose, cardiac, endothelial, neuronal, and pancreatic tissues, among others. We have conducted a thorough …